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SRT1720 is a synthetic compound with SIRT1 activation activity, which can improve oleic acid-induced VSMC mitochondrial respiratory and metabolic dysfunction by activating the SIRT1/PGC-1 pathway, promoting the cell senescence, and inhibiting the transformation of VSMC senescence phenotype [201]

Oxidative stress occurs due to excessive reactive oxygen species (ROS) paired with inadequate levels of antioxidants, in particular glutathione [3]

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PubMed, PDB101: Molecule of the Month: Alcohol Dehydrogenase. RCSB: PDB-101, Accessed 20 Dec

FIGURE 1 3.3 Signal values associated with different GLP-1 RAs We identified signals of AP events associated with all GLP-1 RAs using the criteria established by the four algorithms, and the results are summarized in Table 3